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Following unilateral intrastriatal or medial forebrain bundle injection of 6-hydroxydopamine (6-OHDA)a classical neurotoxin used to mimic parkinsonian neurodegenerationthey observed pronounced leakage of FITC-labeled albumin and horseradish peroxidase into the ipsilateral striatum and substantia nigra at both 10 and 34 days post-lesion

However, it does not directly contribute to faster weight loss

In the 72-week non-diabetic obesity trial, adults lost -15.0% at 5 mg, -19.5% at 10 mg, and -20.9% at 15 mg. Real-world outcomes vary because dose reached, adherence, and baseline state vary