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The link between this principle and autoimmune diseases was then shown in the 1980s, when Imbach and colleagues found that injection of a large pool of exogenous IgG (IVIg) alleviated idiopathic thrombocytopenia (ITP) [94,95,96]

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In gastrointestinal research, BPC-157 is commonly studied through: gastric mucosal integrity intestinal barrier markers ulceration model scoring inflammatory mediator panels blood vessel response histology analysis NO pathway markers oxidative stress markers A 2020 study investigated stable gastric pentadecapeptide BPC-157 in clopidogrel-induced gastric injury models, looking at gastric protection and injury marker changes