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In addition, a near-infrared II (NIR-II) fluorescence/photoacoustic nano-inducer I/E@M2pep which can be activated by nitric oxide (NO), where the M2pep peptide can target M2 TAMs and IPI549 reprograms them into an M1 phenotype, and can significantly enhance antitumor immunity through M1 TAM-mediated tumor killing and TME remodeling when combined with a CD47 monoclonal antibody (57)

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doi: 10.1080/1061186x.2022.2070173 71 ZhouSChengFZhangYSuTZhuG