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We extracted 371 observations from 25 prospective cohort studies and 53 casecontrol studies across 25 locations (Supplementary Table 3) 5,6,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107

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The initial rollout targets Italy, Poland, the Czech Republic, and Greece, with broader European expansion planned for 2023, reinforcing Imperial's multi-category next-generation products (NGP) strategy that includes vapes and oral nicotine innovations