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Mechanically, pre-clinical evidence highlights VNS as a multifaceted therapy for IBS, including reducing inflammation via 7 nicotinic acetylcholine receptor-mediated suppression of TNF-, alleviating visceral hypersensitivity, increasing colorectal distension thresholds, enhancing motility through M3 receptor activation and gastric emptying, restoring gut microbiota diversity via elevating bifidobacterium abundance and short-chain fatty acids, and improving intestinal barrier integrity

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Regular checks are needed to adjust the treatment plan

Genome-wide association studies have demonstrated that CDKN2B-AS1 is one of the most important non-population-specific genes associated with glaucoma 13,14