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Graphical Abstract Similar content being viewed by others Introduction Diabetes mellitus (DM), which is regarded as the disease of the 21 st Century, is a growing epidemic health problem, characterized by elevated blood glucose as a result of either insufficient insulin production by the pancreas or a result of ineffective use of the insulin produced (WHO 2021)

Research indicates that zinc helps preserve sperm structure and function, particularly by reducing oxidative stress, cell death, and DNA fragmentation in men with asthenozoospermia [92]

Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in longterm foodrestricted sheep, but increases growth hormone irrespective of bodyweight