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We speculate, that modulating homeostatic balance in microglia, could have promising therapeutic potential in withdrawal, tolerance, and abstinence-related neural adaptations in nicotine addiction, in the adolescent brain

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"Lots of concerns raised by African countries, Latin American countries, Asian countries that do not feel they are prepared for this epidemic of heated tobacco products." Da Costa said evidence is accumulating that the nicotine inhaled from HTPs is unhealthy, causing dependence and disease

In the European Union, the Tobacco Products Directive (TPD) and ongoing discussions around flavor ban extensions, similar to those already applied to cigarettes and e-cigarettes in certain member states, pose a structural risk to the flavored shisha tobacco segment that could materially impact market growth in one of the world's most important regions