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These are the same harmful compounds found in traditional tobacco and are major causes of cancer and cellular damage over time. He adds that many patients arriving at clinics suffer from severe coughing, hoarseness, dark or yellow phlegm, and in some cases have been diagnosed with pre-cancerous lesions on the vocal cords

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In March 2018, the FDA issued an advance notice of proposed rulemaking to request public comment to better understand the role that flavors in tobacco products play in attracting youth

Follow-up, in years between survey enrollment and death or survival until December 31, 2015, ranged from 1 to 28 years (mean = 13.6 years