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An imbalance in copper levels in the brain has been reported to be associated with many neuropathic diseases, such as depression, Alzheimers disease, Menkes disease, and Wilsons disease (An et al., 2022)

Located in the basement membrane, they interact with the endothelium through both physical contacts that penetrate the basal lamina and via amacrine signaling

Indeed, homocysteine neurotoxic properties have been attributed to NMDA receptor stimulation, auto-oxidation elevating oxidative stress, mitochondrial complex I inhibition, and allosteric D2 receptor antagonism (88)