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The method of embodiment 17, wherein the thiol or a derivative thereof is methionine

Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties

In a B16F10 cell-induced xenograft melanoma murine model, LSPL-1 improved survival time, elicited an immunostimulatory response, and significantly reduced tumor volume in a dose-dependent manner

These studies collectively underscore the importance of metabolomics in identifying biomarkers, perturbed pathways, and potential therapeutic targets in OA