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doi: 10.3109/10715762.2014.945925

Presence of mutation(s) in the gamma-glutamylcysteine synthetase genes

Imbalance in the OPG and RANKL properties is directly associated with the differentiation and activity of osteoclasts and favors bone resorption

indeed, inhibition of glutamate transport in the guinea pig cerebral cortex in vitro has been shown to result in characteristic changes in the tissue metabolome [399]