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Drug Dev Ind Pharm , 2011, 37(11): 1282-1289

Overall, these findings collectively demonstrate that the molecular ruthenium catalyst Ru(II)-OH and the nanoparticle formulation NP2 are therapeutically active in a 21% O 2 atmosphere, but these lose their therapeutic efficiency in a 1% O 2 atmosphere

The clinical data referenced in this article are from the published research available at the time of writing

DecramerMRutten-van MlkenMDekhuijzenPNTroostersTvan HerwaardenCPellegrinoRet alEffects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (bronchitis randomized on NAC cost-utility study, BRONCUS): a randomised placebo-controlled trial