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Theres no clear indication that one-time vape isnt going to be the problematic situation. The CDC found that 75 to 80 percent of patients reported use of THC, while 58 percent used nicotine-containing products, 15 percent used products with nicotine but not THC, and 13 percent used only nicotine-containing products within the 90 days before symptoms emerged

Nicotine absorption profile among regular users of a pod-based electronic nicotine delivery system