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This triple therapy [2] approach leverages the complementary actions of GLP-1, GIP, and glucagon receptors to produce a more comprehensive and effective treatment compared to single or dual agonist drugs

It was found that pardaxin, a marine antimicrobial peptide, can act on the mitochondrial membrane, reduce the potential of mitochondrial membrane, release cytochrome c (cyt c) in the cytoplasm, and release a large amount of reactive oxygen species (ROS)

Trial candidates are generally adults with type 2 diabetes and a BMI over 30 who have not achieved adequate glucose or weight control with standard therapies like metformin or a single GLP-1 agonist

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