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Figure 7 2.7 Potential molecular mechanisms of drug synergies In both the double and triple drug combinations, processes generating ROS (NADH dehydrogenase, NADH quinone oxidoreductase/complex I) and antioxidant activities are significantly dysregulated ( Figures 7A, B )

5 This article was written by McKayla Narveson, PharmD Candidate in collaboration with Eric Christianson, PharmD, BCPS, BCGP 10 Commandments of Polypharmacy Webinar based on my experiences in clinical practice Vaqar S, Shackelford KB

In aorta rings without endothelium, the vascular relaxation induced by BPC 157 was markedly attenuated (Fig