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Additionally, glutathione supports the function of vitamin C, which is essential for collagen synthesis

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The ICR researchers hope that targeted SLC7A11 inhibitors can be developed in the future and trialled for the treatment of melanoma

Nrf2/Keap1/ARE Redox Regulatory Pathway In response to oxidative or xenobiotic stress, Nrf2 dissociates from its inhibitor Keap1, translocates to the nucleus, and binds antioxidant response elements (ARE) to induce expression of genes involved in antioxidant defense and GSH biosynthesis (41)