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Decreased expression of GSH synthesis leads to low free GSH levels, resulting in elevated ROS, immune dysfunction, and increased disease severity in COVID-19 patients 592

doi: 10.1016/S0016-5085(20)33220-0

These distinct mechanisms highlight why both approaches can be complementary in combating oxidative stresshydrogen water provides immediate protection against the most damaging free radicals, while GR ensures long-term maintenance of the glutathione antioxidant system

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