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It is therefore suggesting that the slight change of relaxation observed in the aorta without endothelium ex vivo might be due to some mechanism unrelated to the direct nitric oxide stimulation which needs further investigation

The meta-analytical study shows decreased abundance in the MDD patients when compared to controls in the bacterial families Veillonellaceae, Prevotellaceae, and Sutterellaceae, genera Coprococcus, Faecalibacterium, Ruminococcus, Bifidobacterium, Escherichia , and shows an increase in abundance in Actinomycetaceae family and Paraprevotella genus (Sanada et al., 2020)

The trial did not meet its efficacy endpoint, but tolerability was not the reason the program was discontinued