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238,242 Isocitrate dehydrogenase 3 (IDH3), a pivotal rate-limiting enzyme in the TCA cycle, is downregulated, leading to oxidative phosphorylation uncoupling and lactate accumulation in the brains of AD patients and AD transgenic mice

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The characteristic odor associated with glutathione is primarily due to its sulfur content

Certain groups are more prone to B12 deficiency, including older adults, individuals with gastrointestinal conditions (such as Crohns disease or celiac disease), those who have undergone gastric surgery, or people with dietary restrictions