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FOXO4-DRI theoretically has higher selectivity by targeting the FOXO4-p53 interaction that is specifically elevated in senescent cells

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In patients with AITD, autoreactive lymphocytes infiltrate the thyroid parenchyma, where they recognize thyroid antigens: Tg, TPO, TSH-R, and the sodium iodide symporter ( + lymphocytes and cytotoxic CD8 + lymphocytes ( In the pathogenesis of AITD, cells of both adaptive (specific) immunity - CD4 + -, CD8 + -lymphocytes, peripheral regulatory T-cells (pTreg), etc

Kakumanu S, Tagne JB, Wilson TA, Nicolosi RJ