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FSH and E2 synergistically encourage GCs to create LHR in preparation for the subsequent LH signal

The latter is a competitor of 2-Oxoglutarate-dependent dioxygenases such as Ten-eleven translocation methylcytosine dioxygenase and therefore induces DNA hydroxymethylation and gene upregulation 52

Pernicious anemia is a very rare autoimmune disorder that does not allow for proper vitamin B12 absorption which ultimately leads individuals to have an irreversible deficiency in this vitamin

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