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Experimental investigations have demonstrated that Dihexa modulates HGF-associated signaling pathways involved in cellular communication, synaptic regulatory mechanisms, and receptor-mediated signal transduction

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When IgG4-RD involves the central nervous system or surrounding areas, it may cause: Persistent headaches Eye pain or swelling Facial numbness Neurological symptoms like vision or hearing changes Chronic sinus problems These symptoms may resemble migraines, tension-type headaches, or sinus infections, which is why understanding the link between IgG4-RD and chronic headaches is essential