images of tobacco side effects What Nicotine Does to Your Body Health Effects of Tobacco Use

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Psychoneuroendocrinology 6(4):355357 Funabashi T, Sano A, Mitsushima D, Kimura F (2005) Nicotine inhibits pulsatile luteinizing hormone secretion in human males but not in human females, and tolerance to this nicotine effect is lost within one week of quitting smoking

Before the '20s to '50s, say 80 years before that, they didn't have packaging to know what 80-year-old tobacco would be like, so you have that window of packaging that was made without that knowledge

However, smoking any combusted plant matter introduces potential irritants into your airways and lungs