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302 Notably, microbial metabolites produced by commensal gut flora can limit pathogenic activities of microglia and astrocytes and suppress CNS inflammation in MS experimental models 303 and can contribute to the induction of specific LAMP1+TRAIL+ astrocytes that limit CNS inflammation by inducing T cell apoptosis

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Examples of such interventions include genome editing with CRISPR at the genetic level, antisense oligonucleotides (ASOs) at both, the transcriptional and post-transcriptional level, and the use of small-molecule drugs to target molecular pathways at the translational, or protein level

& Klaassen, C