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[DOI] [PubMed] [Google Scholar] Cotgreave IA, Berggren M, Jones TW, et al

My understanding is the advantage of that is you don't get the negative feedback

Efficacy of low-dose methotrexate in rheumatoid arthritis

CDG2L) is an autosomal recessive disorder that results from deficiencies in the gene encoding component of oligomeric Golgi complex-6 (gene symbol: COG6)