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& Moldovan, L

J Clin Invest 2013;123, 966-972, doi:10.1172/JCI64098

Key Points The value of many promising drug candidates is diminished by the presence of barriers between blood and brain that possess both structural and enzymatic components at the level of the cerebral capillaries, the epithelia of the choroid plexuses and other circumventricular organs, and the arachnoid membranes

If that would not be enough, there is also a 2014 study showing that Pitera might be able to help with skin pigmentation and a 2015 study finding that Galactomyces Ferment Filtrate can activate aryl hydrocarbon receptor (AhR) that's important in epidermal homeostasis by upregulating epidermal barrier proteins