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Blood System: Under the stimulation of chronic hypoxia, the expression of hypoxia inducible factors is activated, thereby stimulating the kidneys and liver to secrete a large amount of EPO ( Renal System: During acute hypoxia, activation of the adrenergic system leads to tachycardia

Furthermore, omega-3 PUFAs and their metabolites (i.e., specialized pro-resolvin mediators), could effectively ameliorate uncontrolled inflammatory responses, reduce OxS, mitigate coagulopathy, and restore tissue homeostasis 715

Therefore, patients must always wear a broad-spectrum sunscreen that guards against both UVA and UVB rays, which can stimulate melanocytes to produce melanin

Med 42 (2012) 1126, 10.1053/j.semnuclmed.2011.07.005