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The combination of Met and Malaysian propolis was found to be the most effective anti-hyperglycaemic therapy, resulting in increased weight of epididymis, testis, seminal vesicle, prostate, reduced NF-kB-mediated inflammation, apoptosis, and epididymal-testicular OS []

It can also affect immunosuppressants such as cyclosporine and some antipsychotics

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Though it is essential to achieve glucose management as soon as possible to reduce the impact of glucose toxic effects, it is also vital to provide treatment to control other associated risks, such as oxidative stress, dyslipidemia, mitochondrial dysfunction, vascular complications, and so on ( Table 1 ) (6467)