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According to a study, Cu/Zn-SOD is not necessary for life, but Mn-SOD knockout mice die before reaching three weeks of age

In summary, due to the higher frequency of MTHFR polymorphism in various psychiatric disease, supplement of folate and cobalamin might be critical when patients with MTHFR deficiency

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Lipoic acid prevented NOX-induced superoxide production in a rat model of cerebral ischemia and limited infarct volume and neurological deficiencies through upregulating the insulin-phosphatidylinositide-3 kinase (PI3K)-protein kinase B (PKB/Akt) signaling pathway (40)