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Over time, these processes have led to the emergence of many superbugs. For example, surveillance data show that 42% of Escherichia coli isolates worldwide are resistant to third-generation cephalosporins and 15% of Staphylococcus aureus isolates are methicillin-resistant (MRSA) in elderly individuals

This represents a rapid, efficient and reversible way to shut down or activate protein activity/function ( 2 H) and to the irreversible sulfonic acid state (SO 3 H)

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