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GLP1 medications such as semaglutide or tirzepatide have robust evidence and multiple FDA indications for obesity and diabetes, with average weightloss outcomes often greater than older agents

Genomics 79 TakesawaT.ItoM.KanzakiH.KameyaN.NakamuraI

In this Review, we discuss the progress made in the development of such modulators for the treatment of depression, and examine recent preclinical and translational studies that have investigated the mechanisms of action of glutamate-targeting antidepressants

This initially increases uptake into the hepatocyte and rate of metabolism and plasma levels of free drug do not change significantly