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Both reasons are valid but the approach, expectations, and oversight should differ accordingly

Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

Common side effects include injection site reactions (burning, pain, swelling, redness), headache, mild diarrhea, and upset stomach

A deeper understanding of microbial-disease pathways could lead to more targeted treatments, the researchers wrote in their study, published today (June 24) in the journal Science Translational Medicine