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Hydrogen peroxide is mainly neutralized by the enzyme catalase, which turns hydrogen peroxide into water and oxygen, and the tripeptide glutathione (GSH), which converts hydrogen peroxide into water through a reducing reaction catalyzed by the enzyme glutathione peroxidase (GPX)

NADPH levels were assessed by measuring the fluorescence ratio at 407 and 482 nm (Olympus IX83 microscope), with quantification performed in ImageJ, as described previously 29

Many patients begin to notice subtle improvements in skin brightness after several sessions

To explore the relevance of GSH to the distinct redox properties of FoB and MZB in vivo, we generated B cell-specific Gclc -deficient mice by crossing Gclc fl/fl mice with Mb1-Cre + mice ( Gclc fl/fl Mb1-Cre + ), in which the Cre recombinase gene is expressed under the control of the B cell-specific promoter Mb1 46