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Although it is not possible to determine from this study which of the micronutrients or their combination is responsible for the observed immune reconstitution, several of the B vitamins and vitamins C and E have previously been shown to enhance cellular immunity.31,32 Supplementation of HIV-infected African women with these nutrients significantly improved CD4+, CD8+, and CD3+ cell counts, and this beneficial effect was sustained for a median of 5 years.23 Moreover, the supplement used in our study included 3 additional antioxidants (acetyl l-carnitine, N-acetyl-cysteine, and alpha lipoic acid)