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10.1046/j.1365-313X.2002.01476.x 129 YamaneK.MitsuyaS.TaniguchiM.MiyakeH

M.ElferinkL

The function of the guiding bar, as postulated in our previous report 16 , could be strengthened by the crystal structure, and disruption of the guiding bar led to an increase in Trx-reduction efficiency, which further supports its importance for regulatory processes in catalysis of TrxR1

However, if serum cobalamin concentration is within the normal range, treatment should be continued at least monthly and the owner should be forewarned that clinical signs may recur sometime in the future