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Larger and long-term studies are warranted to generate more evidence

This difference is widely believed to be due to aging-related changes such as immunosenescence, but direct evidence is still lacking (108)

Reduced inflammation ( IL-6, TNF-) Lowered oxidative stress ( ROS, HO-1/NQO-1) Restored key barrier proteins (FLG, LOR, AQP3) Enhanced cell repair and anti-apoptotic activity This study unveils a new bio-based approach to photoprotection and barrier restoration, positioning fermented polysaccharides as promising ingredients for sensitive-skin and after-sun formulations

The reasons cited by the FDA included concerns about immunogenicity, peptide impurity characterization challenges, and the lack of adequate safety data from human clinical trials