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The disclosure also contemplates the use of one or more of the formulations or compositions, in the manufacture of medicaments for treating, abating, reducing, or ameliorating the symptoms of a disease, dysfunction, or disorder in a mammal, such as a human that has, is suspected of having, or at risk for developing an auris interna disorder

No trials specifically enrolled elderly individuals, those with significant cardiovascular disease, individuals with active cancer, or pregnant/breastfeeding women

3 While data on the safety of dual cytokine inhibition in psoriasis are limited, patients in clinical trials for psoriatic arthritis often are treated with a biologic and methotrexate and/or oral corticosteroids

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