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In vivo evaluations of these metabolic regulators would involve (i) animal models fed an HFD to induce obesity in order to assess the effects of activating or inhibiting these regulators on adipose tissue development, insulin sensitivity, and overall metabolic health

However, oxidative modification of Keap1 by ROS removes its inhibitory effects on Nrf2 and allows for Nrf2-mediated transcription of antioxidant related genes (Sekhar et al., 2010)

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Advances in the use of nanotechnology for treating gout