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Improved insulin sensitivity also reduces the risk of developing metabolic diseases and supports better overall metabolic health

Additionally, 35% of subjects in the Tesamorelin group achieved a hepatic fat fraction below 5%, compared to only 4% in the control group

Studies using chondrocyte cell models have investigated whether the GH C-terminal fragment influences cartilage matrix synthesis, chondrocyte proliferation, and growth factor expression in bone and cartilage biology research contexts

A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss