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309 Recently, Met restricted diet (MRD) has been reported to have an important role in anti-tumor immune regulation

It appears to work through multiple mechanisms, including enhanced angiogenesis (formation of new blood vessels), upregulation of growth hormone receptors, and modulation of nitric oxide pathways

Phase 2 cagrilintide alone ~10.8% body weight reduction at 26 weeks (4.5mg) Phase 2 CagriSema combo ~15.6% body weight reduction at 32 weeks Phase 3 REDEFINE 1 ~22.7% body weight reduction at 68 weeks Phase 2 CagriSema combination trial The Phase 2 trial of CagriSema was published in The Lancet in 2023, and its results attracted immediate attention

Huazhong University of Science and Technology