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The gene responsible for the proteins that encode GSH synthesis, including SLC7A11 (system Xc-), GCLC/GLCM and GSS, GPX4, etc., and oxidoreductases that use GSH and NADPH to reduce oxidative substrates, such as GSH-S-transferase p1 (GSTP1) and 1 (GSTA1), peroxidase 1 (PRDX1) and 6 (PRDX6), and thioredoxin reductase (TXNRD1) are all targets of Nrf2 (Hayes and Dinkova-Kostova, 2014)

Interaction of SARS-CoV-2 proteins with specific host cellular targets could rewire sugar-, AA-, FA-, as well as nucleotide-metabolism(s), and distinctly alter or impair bioenergetics, immune response, and redox homeostasis in the human body, thereby facilitate viral life cycle 21,22

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Cardiovascular comorbidities of psoriasis and psoriatic arthritis: a report from the GRAPPA 2012 annual meeting