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doi: 10.1073/pnas.64.3.947

SharmaPKaushikPJainSSharmaBMAwasthiRKulkarniGTet al

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This was associated with reduced expression of xCT (the catalytic subunit of Sxc ) and mGlu2 receptors [116], suggesting that a defective endogenous activation of mGlu2 receptors in the nucleus accumbens underlies the altered glutamate homeostasis that is ultimately responsible for the loss of control in drug-seeking behavior and relapse