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Even though the exact structure of the mPTP, as well as its assembly kinetics, is still unknown, interesting findings suggested that dissociation of F 1 F O ATP synthase dimers 45 and the c subunit pore-forming part 46 have an important role in mitochondrial permeability transition (mPT) and constitute a valid therapeutic approach in pathologies subjected to widespread cell death 47,48

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Weeks 4 to 6: meaningful improvement The majority of positive responders report significant subjective improvement during this window