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Needle electrodes are placed at the vertex (active) and immediately below the pinna of the test ear (reference) and contralateral ear (ground)

JACC Basic Transl

The SSRI, which inhibit serotonin transporter SERT/SLC6A4 (expressed in both neurones and astroglia) and thus increase bioavailability of serotonin, are probably the most widely used in the treatment of depression