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WADA prohibits the administration of these substances when used to artificially raise levels beyond normal physiological ranges for the purpose of performance enhancement.

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Mast cells, after IgE-mediated activation by IgE/FcRI cross-linking, or after non-IgE-mediated activation, release a spectrum of mediators of allergic inflammation, such as histamine, prostaglandins, leukotrienes and cytokines [10, 11]

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