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Riboflavin further modulates redox-sensitive transcription factors including Nrf2 and AP-1, thereby inducing downstream antioxidant genes like NQO1, GCLC, and HO-1

Kastenmller are co-inventors (through Duke University/Helmholtz Zentrum Mnchen) on patents on applications of metabolomics in diseases of the central nervous system and hold equity in Chymia LLC and IP in PsyProtix and Atai that are exploring the potential for therapeutic applications targeting mitochondrial metabolism in treatment-resistant depression

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