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From a pharmacokinetic perspective, studies indicate no evidence that the combination of Vitamins B1, B6, and B12 adversely affects the pharmacokinetics of each individual vitamin

In certain embodiments, any controlled-release otic formulation described herein increases the exposure time of an active agent and decreases the C max in otic fluids (e.g., endolymph and/or perilymph) by about 40%, about 30%, about 20%, or about 10%, compared to a formulation that is not a controlled-release otic formulation

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