tobacco in history and culture an encyclopedia Historic Originally used by Native Americans for medicinal Tobacco: A Cultural History of

Harvesting cigar tobacco involves picking the leaves at different stages of maturity

J Child Adolesc Psychopharmacol

acne, acneiform eruptions, allergic dermatitis, alopecia, angioedema, angioneurotic edema, atrophy and thinning of skin, dry scaly skin, ecchymoses and petechiae (bruising), erythema, facial edema, hirsutism, impaired wound healing, increased sweating, Karposis sarcoma (See PRECAUTIONS: General Precautions), lupus erythematosus-like lesions, perineal irritation, purpura, rash, striae, subcutaneous fat atrophy, suppression of reactions to skin tests, striae, telangiectasis, thin fragile skin, thinning scalp hair, urticaria

A lot of people consider this "THE blend for breaking in a new pipe" and I can see why