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LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al

In a disconnected stack, verifying all five requires cross-referencing multiple systems manually

Therefore the principal drug had the greatest role in the treatment of CAG with XJZ, the assistant drug and the complement drug alone had a lesser role, and both mainly played a role together with the principal drug (Figure 7)

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