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It has been used in clinical neurology for years, with an established safety profile and well-documented mechanisms of action

However, when the precursor to sulforaphane, glucoraphanin, was provided in the mothers food during pregnancy and lactation, the pups had significant improvement in cognitive deficits and social interaction and protection from poly(I:C) induced parvalbumin-positive cell loss

A meta-analysis of 18 clinical trials involving 1,883 women with poor ovarian response undergoing IVF or intracytoplasmic sperm injection found supplementing with 75 mg DHEA daily for two to four months reduced the risk of miscarriage by 50%, increased the pregnancy rate by 53%, and increased successful births by 87%

Combined 13-Week Repeated Dose Toxicity Study With the Reproduction/Developmental Toxicity Screening Test by Oral Route (Dietary Admixture) in Rats